Center for Research on Environmental Chemicals in Humans – a 501(c)(3) IRS-approved non-profit

Linking science with valid decisions

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Linking health decisions with valid science

 

 

 

Linking health decisions with valid science

Mission Statement

The Center’s mission is to enable individuals and health professionals to take medically valid actions to avoid the risks of Endocrine and Epigenetic Disrupting Chemicals (EEDCs). The CDC says that EEDCs are found in most Americans.

To do this, our first-ever human research is designed to establish a scientific cause-and-effect connection between EEDCs and their effects on clinically proven health indicators such as standard hospital blood tests. Read more

Supporting The First Controlled Human Study

The Committee on Human Research (CHR) at the University of California San Francisco Medical School has approved the Stealth Syndromes Study experimental protocol.

This "proof of concept" study is designed to determine if standard clinical blood tests can be used to detect physiological changes that may be caused by the absorption of environmental chemicals, including endocrine disrupting compounds. Read more about the study here.

What is an Environmental Chemical?

Environmental chemicals are those which surround us and which we absorb through the air we breathe and via food, beverages, and physical contact.

CRECH focuses primarily on a subset of the chemicals that are active in very low concentrations: parts per billion and parts per trillion. These chemicals alter body functions in two primary ways:

(1) By altering hormone functions. These are called endocrine disruptors.

(2) By altering the proper function of genes. These are epigenetic disruptors.

Because endocrine and epigenetic disruptors (EEDCs) are active in such small quantities, traditional toxicology techniques used for chemical regulation are obsolete and ineffective at assessing their dangers

In the United States,the Centers for Disease Control (CDC) has found that many EEDCs are continually stored in our bodies. The CDC tracks many of these chemicals through their National Health and Nutrition Examination Survey (NHANES).
Read more.

CRECH Transparency: IRS Filings, Guidestar & More

The Center for Research on Environmental Chemicals in Humans was approved by the IRS for 501(c)(3) non-profit status on June 28, 2017.

  • IRS Approval letter for 501(c)(3) Non-Profit Status
  • Guidestar profile
  • CRECH IRS Form 1023 as approved
  • CRECH IRS Form 1023 Narrative

Click here for more details

What’s Involved With The Stealth Syndromes Study?

A non-scientist's look at what the Stealth Syndromes Study involves:

  • Where Did The Idea Come From?
  • How Will The Process Work?
  • The Need To Control Micronutrients
  • How Do Science & Society Benefit?

Humans: The #1 Missing Link

The absence of controlled trials on humans is the biggest missing link.

The proof-of-concept Stealth Syndrome Study supported by The Center for Research on Environmental Chemicals in Humans will be the first because it pioneered the protocol to overcome the ethical issues.

Moving from “link” to “cause”

In the absence of human studies, hundreds of recent, peer-reviewed studies published in the most elite scientific journals have linked low level exposures of Bisphenol A, for example, to cancer, obesity, diabetes as well as reproductive and developmental harm. Read more.

Of Mice, Humans and Ethics

No previous human trials have been conducted because it is unethical to deliberately expose humans to chemicals suspected of being harmful. This is why rats and mice (known as a murine model) are commonly used as well as more advanced laboratory methods

The murine model has proven to be an exceptionally valuable tool for biomedical research.The same is true of "in vitro" methods which use instruments to focus on specific cellular pathways or the reactions of specific laboratory cell cultures to chemicals.

As vital as those methods are, is no guarantee that identical effects will be seen in humans. This is often cited as a reason why new pharmaceuticals often fail in trials with humans.

Why Have Regulators Failed To Regulate?

Federal regulators such as the Food and Drug Administration and the Environmental Protection Agency have failed to classify most environmental chemicals as harmful because of outdated science, archaic regulations, and the failure to consider peer-reviewed, published studies conducted by university scientists.
Read more.

About The Center

The Center for Research on Environmental Chemicals in Humans was founded in 2017 to provide support and financing for the first controlled human trials of the low-level effects environmental chemicals (including endocrine disruptors).

The need for the Center's work grew out of the past four years of experience by the The Stealth Syndromes Project and its research arm, the Stealth Syndromes Study.

Read more.

The Center’s Projects

Stealth Syndromes Human Study -- Approved by the University of California, San Francisco Medical School's Committee on Human Research in 2015, this is the controlled first human study of environmental chemicals. This effort is the #1 priority for CRECH and the object of fundraising.

The Stealth Syndromes Project -- This multi-year endeavor began as an effort to clarify environmental risks for a non-scientific audience. The founders have supported this multi-year project from personal time and funds.

PharmBlockers -- -- This is a fledgling effort that has resulted from Stealth Syndrome Project research which discovered that some environmental chemicals work in ways that counteract approved pharmaceuticals. READ MORE ABOUT THESE CRECH PROJECTS.

Who Are We?

The center's Co-Founder Biographies

Lewis Perdue, Project Co-Founder, Co-principal Investigator

Becca L. Yeamans-Irwin, Collaborator, Project Co-Founder

 

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Click here for Guidestar Profile, IRS Filing and Documents

The Center for Research on Environmental Chemicals in Humans needs your help to conduct the world’s first study of environmental chemicals in humans.

The research has been supported since 2013 by the personal funds and volunteer efforts of Co-Founders Lewis Perdue, Co-Founder and Becca L. Yeamans-Irwin.

However, the approval of a revolutionary protocol by the Committee on Human Research at the University of California Medical School demands a strict set of laboratory and test procedures requiring far more resources to accomplish this first-of-a-kind study.

Producing Valuable Health Information For Non-Scientists

That four-year. initial volunteer effort has produced substantial health information to help non-scientists understand how environmental chemicals affect their health.

That content found at The Stealth Syndromes Project.

Developing Landmark Study For Risk Assessment

In addition the co-founders — with the invaluable volunteer support of UCSF Professor and Co-Principal Investigator Victor Reus— developed the unique study protocol that led to the first approval of a controlled human study a CHR at any major research institution.

More about that effort can be found at The Stealth Syndromes Human Study

New Risk Assessment Method Created

That effort has also resulted in the development of a potential new method for environmental chemical risk assessment: The PharmBlocker method.

Approved Research Now Moves To An Expensive New Phase

With that approval, the study moves into a new phase that requires substantial financial expenses due to the costs of sophisticated laboratory testing of test subject blood and urine samples.

Also expensive are the required laboratory assays of each meal consumed in order to directly measure environmental chemical concentrations and to establish precise nutritional composition.

 

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